Iran has flatly rejected U.S. demands to curb uranium enrichment, setting the stage for a more confrontational phase in nuclear negotiations between the two countries.

Foreign Minister Abbas Araghchi has said that enrichment is not up for discussion, after President Donald Trump‘s White House toughened its stance, with envoy Steve Witkoff saying Iran “must stop and eliminate its nuclear enrichment and weaponization program.”

Newsweek has reached out to the State Department and Iran’s foreign ministry for comment.

Why It Matters

The Iranian response underscores growing tension as both sides harden their positions ahead of further talks. With no signs of flexibility from Tehran, and Washington also linking the talks to broader missile and defense concerns, it increases the risk of failure and renewed conflict.

The U.S. shift appears to set a higher bar than the 2015 nuclear deal. Iran’s refusal to consider such terms could derail diplomacy and increase the likelihood of military confrontation.

The inclusion of missile stockpiles and defense capabilities as concerns by American officials, though not formal agenda items, has further increased tensions.